FUNCTIONAL STATE OF VASCULAR ENDOTHELIUM IN HYPERHOMOCYSTEINEMIA IN CHILDREN WITH ARTERIAL HYPERTENSION

Background. Homocysteine is a sulfur-containing amino acid that can have damaging effect on the vascular endothelium, being an independent risk factor for development of cardiovascular pathology. The purpose. To evaluate functional state endothelium in hyperhomocysteinemia children with arterial hypertension. Material and methods. 111 aged 14 to 18 years were examined. All patients divided into 3 groups:group I (n=51) consisted hypertension, group II (n=30) included those high normal blood pressure, III was composed 30 healthy children. Plasma homocysteine determined by high-pressure liquid chromatography. Results. concentration increases pressure hypertension compared Pathological decrease endothelium-dependent vasodilation accompanied increase plasma.